Evolution and architecture of the inner membrane complex in asexual and sexual stages of the malaria parasite.
Identifieur interne : 001237 ( Main/Exploration ); précédent : 001236; suivant : 001238Evolution and architecture of the inner membrane complex in asexual and sexual stages of the malaria parasite.
Auteurs : Maya Kono [Allemagne] ; Susann Herrmann ; Noeleen B. Loughran ; Ana Cabrera ; Klemens Engelberg ; Christine Lehmann ; Dipto Sinha ; Boris Prinz ; Ulrike Ruch ; Volker Heussler ; Tobias Spielmann ; John Parkinson ; Tim W. GilbergerSource :
- Molecular biology and evolution [ 1537-1719 ] ; 2012.
English descriptors
- KwdEn :
- Cell Line, Cell Membrane Structures (metabolism), Cell Polarity, Cytoskeleton (metabolism), Female, Humans, Male, Phylogeny, Plasmodium (genetics), Plasmodium (growth & development), Plasmodium (metabolism), Protein Transport, Protozoan Proteins (chemistry), Protozoan Proteins (genetics), Protozoan Proteins (metabolism), Sequence Homology, Amino Acid.
- MESH :
- chemical , chemistry : Protozoan Proteins.
- genetics : Plasmodium, Protozoan Proteins.
- growth & development : Plasmodium.
- metabolism : Cell Membrane Structures, Cytoskeleton, Plasmodium, Protozoan Proteins.
- Cell Line, Cell Polarity, Female, Humans, Male, Phylogeny, Protein Transport, Sequence Homology, Amino Acid.
Abstract
The inner membrane complex (IMC) is a unifying morphological feature of all alveolate organisms. It consists of flattened vesicles underlying the plasma membrane and is interconnected with the cytoskeleton. Depending on the ecological niche of the organisms, the function of the IMC ranges from a fundamental role as reinforcement system to more specialized roles in motility and cytokinesis. In this article, we present a comprehensive evolutionary analysis of IMC components, which exemplifies the adaptive nature of the IMCs' protein composition. Focusing on eight structurally distinct proteins in the most prominent "genus" of the Alveolata-the malaria parasite Plasmodium-we demonstrate that the level of conservation is reflected in phenotypic characteristics, accentuated in differential spatial-temporal patterns of these proteins in the motile stages of the parasite's life cycle. Colocalization studies with the centromere and the spindle apparatus reveal their discriminative biogenesis. We also reveal that the IMC is an essential structural compartment for the development of the sexual stages of Plasmodium, as it seems to drive the morphological changes of the parasite during the long and multistaged process of sexual differentiation. We further found a Plasmodium-specific IMC membrane matrix protein that highlights transversal structures in gametocytes, which could represent a genus-specific structural innovation required by Plasmodium. We conclude that the IMC has an additional role during sexual development supporting morphogenesis of the cell, which in addition to its functions in the asexual stages highlights the multifunctional nature of the IMC in the Plasmodium life cycle.
DOI: 10.1093/molbev/mss081
PubMed: 22389454
Affiliations:
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Loughran</name></author><author><name sortKey="Cabrera, Ana" sort="Cabrera, Ana" uniqKey="Cabrera A" first="Ana" last="Cabrera">Ana Cabrera</name></author><author><name sortKey="Engelberg, Klemens" sort="Engelberg, Klemens" uniqKey="Engelberg K" first="Klemens" last="Engelberg">Klemens Engelberg</name></author><author><name sortKey="Lehmann, Christine" sort="Lehmann, Christine" uniqKey="Lehmann C" first="Christine" last="Lehmann">Christine Lehmann</name></author><author><name sortKey="Sinha, Dipto" sort="Sinha, Dipto" uniqKey="Sinha D" first="Dipto" last="Sinha">Dipto Sinha</name></author><author><name sortKey="Prinz, Boris" sort="Prinz, Boris" uniqKey="Prinz B" first="Boris" last="Prinz">Boris Prinz</name></author><author><name sortKey="Ruch, Ulrike" sort="Ruch, Ulrike" uniqKey="Ruch U" first="Ulrike" last="Ruch">Ulrike Ruch</name></author><author><name sortKey="Heussler, Volker" sort="Heussler, Volker" uniqKey="Heussler V" first="Volker" last="Heussler">Volker Heussler</name></author><author><name sortKey="Spielmann, Tobias" sort="Spielmann, Tobias" uniqKey="Spielmann T" first="Tobias" last="Spielmann">Tobias Spielmann</name></author><author><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name></author><author><name sortKey="Gilberger, Tim W" sort="Gilberger, Tim W" uniqKey="Gilberger T" first="Tim W" last="Gilberger">Tim W. 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Loughran</name></author><author><name sortKey="Cabrera, Ana" sort="Cabrera, Ana" uniqKey="Cabrera A" first="Ana" last="Cabrera">Ana Cabrera</name></author><author><name sortKey="Engelberg, Klemens" sort="Engelberg, Klemens" uniqKey="Engelberg K" first="Klemens" last="Engelberg">Klemens Engelberg</name></author><author><name sortKey="Lehmann, Christine" sort="Lehmann, Christine" uniqKey="Lehmann C" first="Christine" last="Lehmann">Christine Lehmann</name></author><author><name sortKey="Sinha, Dipto" sort="Sinha, Dipto" uniqKey="Sinha D" first="Dipto" last="Sinha">Dipto Sinha</name></author><author><name sortKey="Prinz, Boris" sort="Prinz, Boris" uniqKey="Prinz B" first="Boris" last="Prinz">Boris Prinz</name></author><author><name sortKey="Ruch, Ulrike" sort="Ruch, Ulrike" uniqKey="Ruch U" first="Ulrike" last="Ruch">Ulrike Ruch</name></author><author><name sortKey="Heussler, Volker" sort="Heussler, Volker" uniqKey="Heussler V" first="Volker" last="Heussler">Volker Heussler</name></author><author><name sortKey="Spielmann, Tobias" sort="Spielmann, Tobias" uniqKey="Spielmann T" first="Tobias" last="Spielmann">Tobias Spielmann</name></author><author><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name></author><author><name sortKey="Gilberger, Tim W" sort="Gilberger, Tim W" uniqKey="Gilberger T" first="Tim W" last="Gilberger">Tim W. Gilberger</name></author></analytic><series><title level="j">Molecular biology and evolution</title><idno type="eISSN">1537-1719</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Line</term><term>Cell Membrane Structures (metabolism)</term><term>Cell Polarity</term><term>Cytoskeleton (metabolism)</term><term>Female</term><term>Humans</term><term>Male</term><term>Phylogeny</term><term>Plasmodium (genetics)</term><term>Plasmodium (growth & development)</term><term>Plasmodium (metabolism)</term><term>Protein Transport</term><term>Protozoan Proteins (chemistry)</term><term>Protozoan Proteins (genetics)</term><term>Protozoan Proteins (metabolism)</term><term>Sequence Homology, Amino Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Protozoan Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Plasmodium</term><term>Protozoan Proteins</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Plasmodium</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Membrane Structures</term><term>Cytoskeleton</term><term>Plasmodium</term><term>Protozoan Proteins</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line</term><term>Cell Polarity</term><term>Female</term><term>Humans</term><term>Male</term><term>Phylogeny</term><term>Protein Transport</term><term>Sequence Homology, Amino Acid</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The inner membrane complex (IMC) is a unifying morphological feature of all alveolate organisms. It consists of flattened vesicles underlying the plasma membrane and is interconnected with the cytoskeleton. Depending on the ecological niche of the organisms, the function of the IMC ranges from a fundamental role as reinforcement system to more specialized roles in motility and cytokinesis. In this article, we present a comprehensive evolutionary analysis of IMC components, which exemplifies the adaptive nature of the IMCs' protein composition. Focusing on eight structurally distinct proteins in the most prominent "genus" of the Alveolata-the malaria parasite Plasmodium-we demonstrate that the level of conservation is reflected in phenotypic characteristics, accentuated in differential spatial-temporal patterns of these proteins in the motile stages of the parasite's life cycle. Colocalization studies with the centromere and the spindle apparatus reveal their discriminative biogenesis. We also reveal that the IMC is an essential structural compartment for the development of the sexual stages of Plasmodium, as it seems to drive the morphological changes of the parasite during the long and multistaged process of sexual differentiation. We further found a Plasmodium-specific IMC membrane matrix protein that highlights transversal structures in gametocytes, which could represent a genus-specific structural innovation required by Plasmodium. We conclude that the IMC has an additional role during sexual development supporting morphogenesis of the cell, which in addition to its functions in the asexual stages highlights the multifunctional nature of the IMC in the Plasmodium life cycle.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Hambourg</li></region><settlement><li>Hambourg</li></settlement></list><tree><noCountry><name sortKey="Cabrera, Ana" sort="Cabrera, Ana" uniqKey="Cabrera A" first="Ana" last="Cabrera">Ana Cabrera</name><name sortKey="Engelberg, Klemens" sort="Engelberg, Klemens" uniqKey="Engelberg K" first="Klemens" last="Engelberg">Klemens Engelberg</name><name sortKey="Gilberger, Tim W" sort="Gilberger, Tim W" uniqKey="Gilberger T" first="Tim W" last="Gilberger">Tim W. Gilberger</name><name sortKey="Herrmann, Susann" sort="Herrmann, Susann" uniqKey="Herrmann S" first="Susann" last="Herrmann">Susann Herrmann</name><name sortKey="Heussler, Volker" sort="Heussler, Volker" uniqKey="Heussler V" first="Volker" last="Heussler">Volker Heussler</name><name sortKey="Lehmann, Christine" sort="Lehmann, Christine" uniqKey="Lehmann C" first="Christine" last="Lehmann">Christine Lehmann</name><name sortKey="Loughran, Noeleen B" sort="Loughran, Noeleen B" uniqKey="Loughran N" first="Noeleen B" last="Loughran">Noeleen B. Loughran</name><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name><name sortKey="Prinz, Boris" sort="Prinz, Boris" uniqKey="Prinz B" first="Boris" last="Prinz">Boris Prinz</name><name sortKey="Ruch, Ulrike" sort="Ruch, Ulrike" uniqKey="Ruch U" first="Ulrike" last="Ruch">Ulrike Ruch</name><name sortKey="Sinha, Dipto" sort="Sinha, Dipto" uniqKey="Sinha D" first="Dipto" last="Sinha">Dipto Sinha</name><name sortKey="Spielmann, Tobias" sort="Spielmann, Tobias" uniqKey="Spielmann T" first="Tobias" last="Spielmann">Tobias Spielmann</name></noCountry><country name="Allemagne"><region name="Hambourg"><name sortKey="Kono, Maya" sort="Kono, Maya" uniqKey="Kono M" first="Maya" last="Kono">Maya Kono</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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